THE PREDICTIVE VALUE OF CYTOGENETIC DIAGNOSIS AFTER CVS - 1500 CASES

被引：38

作者：

BREED, ASPM

MANTINGH, A

BEEKHUIS, JR

KLOOSTERMAN, MD

TENBOLSCHER, H

ANDERS, GJPA

机构：

[1] UNIV HOSP GRONINGEN,DEPT OBSTET & GYNAECOL,GRONINGEN,NETHERLANDS

[2] DIAKONESSENHUIS ARNHEM,DEPT OBSTET & GYNAECOL,ARNHEM,NETHERLANDS

来源：

PRENATAL DIAGNOSIS | 1990年 / 10卷 / 02期

关键词：

Chorionic villus biopsy; Discrepancy; Mosaicism; Predictive value; Prenatal diagnosis; Tissue‐specific selection;

D O I：

10.1002/pd.1970100206

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The cytogenetic results of 1500 chorionic villus samples (CVS) are presented. In these 1500 samples, 23 samples (1·5 per cent) could not be provided with a diagnosis because of laboratory failure. This failure rate dropped from 3 per cent in the first 500 samples to 0·2 per cent in the last 500. In the remaining 1477 samples, 58 (3·9 per cent) chromosomal aberrations were found. Of these, 21 (36 per cent) proved not to represent the karyotype of the fetus proper. Predictive values of (different groups of) chromosomal aberrations in CVS are calculated. The impact of (differences between) the predictive value for some major chromosomal aberrations is discussed. A tissue‐ and chromosome‐specific selection mechanism is postulated. Copyright © 1990 John Wiley & Sons, Ltd.

引用

页码：101 / 110

页数：10

共 18 条

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