FIBROBLAST GROWTH-FACTOR IMPROVES THE HEALING OF EXPERIMENTAL TYMPANIC MEMBRANE PERFORATIONS

被引:53
作者
MONDAIN, M
SAFFIEDINE, S
UZIEL, A
机构
[1] ST CHARLES HOSP,DEPT OTOLARYNGOL,F-34059 MONTPELLIER,FRANCE
[2] INSERM,U254,F-34100 MONTPELLIER,FRANCE
关键词
TYMPANIC MEMBRANE; HEALING; FGF; GROWTH FACTOR;
D O I
10.3109/00016489109137397
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
Topical application of FGF (fibroblast growth factor), a potent mitogen for mesodermal and neuroectodermal cells, was given to promote the healing of tympanic membrane perforations in rats. Calibrated tympanic membrane perforations were performed in 30 rats. At day 0, each rat received 40-mu-l of placebo in the right ear and 40-mu-l of a solution containing FGF in the left ear at different concentrations. The quality of healing was observed by otomiscroscopy and by light microscopic examination of histological sections. The mean time of closure was significantly shorter in ears receiving an amount of 400 ng FGF (6.1 days), as compared to non-treated ears (8.8 days). Using a higher dose of FGF, the promoting effect was counterbalanced by a high rate of myringitis. Using a dose of 200 ng of FGF, no difference was noticed between placebo group and FGF group.
引用
收藏
页码:337 / 341
页数:5
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