AUTOGENOUS TRANSLATION REGULATION BY ESCHERICHIA-COLI ATPASE SECA MAY BE MEDIATED BY AN INTRINSIC RNA HELICASE ACTIVITY OF THIS PROTEIN

被引：46

作者：

KOONIN, EV

GORBALENYA, AE

机构：

[1] ACAD SCI USSR, INST MICROBIOL, MOSCOW 117811, USSR

[2] ACAD MED SCI USSR, INST POLIOMYELITIS & VIRAL ENCEPHALITIDES, MOSCOW 142782, USSR

来源：

FEBS LETTERS | 1992年 / 298卷 / 01期

关键词：

AMINO ACID SEQUENCE COMPARISON; CONSERVED SEQUENCE MOTIF; HELICASE; TRANSLATION REGULATION; PROTEIN TRANSPORT;

D O I：

10.1016/0014-5793(92)80009-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The seven conserved motifs typical of the helicase superfamily II have been identified in the sequences of Escherichia coli protein SecA, an ATPase mediating protein translocation across the inner membrane of the bacterium. and its Bacillus subtilis homolog Div. It is hypothesized that SecA and Div possess an RNA helicase activity and may couple ATP hydrolysis both to membrane translocation of proteins. and to hairpin unwinding in their own mRNAs, leading to the known autogenous regulation of translation.

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页码：6 / 8

页数：3

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