CDNA CLONING OF MOUSE VLA-3 ALPHA-SUBUNIT

被引：13

作者：

TAKEUCHI, K ^{[1
]}

HIRANO, K ^{[1
]}

TSUJI, T ^{[1
]}

OSAWA, T ^{[1
]}

IRIMURA, T ^{[1
]}

机构：

[1] UNIV TOKYO,FAC PHARMACEUT SCI,DIV CHEM TOXICOL & IMMUNOCHEM,BUNKYO KU,TOKYO 113,JAPAN

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 1995年 / 57卷 / 02期

关键词：

INTEGRIN; VIA (VERY LATE ANTIGEN); ADHESION MOLECULE; CDNA CLONING; TISSUE DISTRIBUTION;

D O I：

10.1002/jcb.240570221

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

cDNA clones for mouse VLA (very late antigen)-3 alpha subunit (alpha 3 integrin) were isolated and sequenced. The encoded mouse alpha 3 integrin subunit was composed of 1,053 amino acid residues. The results of sequence analysis revealed similar structural characteristics to other VLA alpha subunits. For example, the presence of a large extracellular domain including th ree putative metal binding sequences, a transmembrane domain, and a short cytoplasmic domain. A higher level of its message was detected in thymus than in kidney, stomach, spleen, liver, brain, or lung by Northern blotting analysis. (C) 1995 Wiley-Liss, Inc.

引用

页码：371 / 377

页数：7

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