PHARMACOKINETIC AND PHARMACODYNAMIC INTERACTIONS BETWEEN THE ACE INHIBITOR CILAZAPRIL AND BETA-ADRENOCEPTOR ANTAGONIST PROPRANOLOL IN HEALTHY-SUBJECTS AND IN HYPERTENSIVE PATIENTS

被引：7

作者：

BELZ, GG

ESSIG, J

ERB, K

BREITHAUPT, K

HOOGKAMER, JFW

KNEER, J

KLEINBLOESEM, CH

机构：

[1] ZE KA PHA GMBH,ZENTRUM KARDIOVASC PHARMAKOL,WIESBADEN,FED REP GER

[2] HOFFMANN LA ROCHE LTD,DEPT CLIN RES,BASEL,SWITZERLAND

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1989年 / 27卷

关键词：

D O I：

10.1111/j.1365-2125.1989.tb03498.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：S317 / S322

页数：6

共 14 条

[1]

BELZ GG, 1986, MED KLIN, V81, P524

[2] INTERACTIONS BETWEEN CILAZAPRIL AND PROPRANOLOL IN MAN - PLASMA DRUG CONCENTRATIONS, HORMONE AND ENZYME RESPONSES, HEMODYNAMICS, AGONIST DOSE-EFFECT CURVES AND BARORECEPTOR REFLEX [J].

BELZ, GG ;

ESSIG, J ;

KLEINBLOESEM, CH ;

HOOGKAMER, JFW ;

WIEGAND, UW ;

WELLSTEIN, A .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1988, 26 (05) :547-556

[3] ANGIOTENSIN-CONVERTING ENZYME-INHIBITORS - RELATIONSHIP BETWEEN PHARMACODYNAMICS AND PHARMACOKINETICS [J].

BELZ, GG ;

KIRCH, W ;

KLEINBLOESEM, CH .

CLINICAL PHARMACOKINETICS, 1988, 15 (05) :295-318

[4] HEMODYNAMIC-RESPONSES TO ANGIOTENSIN-I IN NORMAL VOLUNTEERS AND THE ANTAGONISM BY THE ANGIOTENSIN-CONVERTING ENZYME-INHIBITOR CILAZAPRIL [J].

BELZ, GG ;

ESSIG, J ;

WELLSTEIN, A .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1987, 9 (02) :219-224

[5]

BERTRAM B, 1982, Z KARDIOL, V71, P665

[6] EFFECTS OF SINGLE DOSES OF THE CONVERTING-ENZYME-INHIBITOR CILAZAPRIL IN NORMAL VOLUNTEERS [J].

DAMORE, TF ;

BUSSIEN, JP ;

NUSSBERGER, J ;

WAEBER, B ;

TURINI, GA ;

BRUNNER, HR ;

KLER, L ;

FRANCIS, RJ .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1987, 9 (01) :26-31

[7] CAPTOPRIL - CONTRASTING EFFECTS OF ADDING HYDROCHLOROTHIAZIDE, PROPRANOLOL, OR NIFEDIPINE [J].

MACGREGOR, GA ;

MARKANDU, ND ;

SMITH, SJ ;

SAGNELLA, GA .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1985, 7 :S82-S87

[8]

NUSSBERGER J, 1987, J CARDIOVASC PHARM, V9, P39, DOI 10.1097/00005344-198701000-00007

[9]

PRICHARD B N C, 1987, Journal of Cardiovascular Pharmacology, V10, pS6, DOI 10.1097/00005344-198710110-00003

[10] THE HYPOTENSIVE EFFECT OF PROPRANOLOL IN CAPTOPRIL-TREATED PATIENTS DOES NOT INVOLVE THE PLASMA RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM [J].

STAESSEN, J ;

FAGARD, R ;

LIJNEN, P ;

VERSCHUEREN, LJ ;

AMERY, A .

CLINICAL SCIENCE, 1981, 61 :S441-S444

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