H-RAS MUTANTS LACKING THE EPITOPE FOR THE NEUTRALIZING MONOCLONAL ANTIBODY-Y13-259 SHOW DECREASED BIOLOGICAL-ACTIVITY AND ARE DEFICIENT IN GTPASE-ACTIVATING PROTEIN-INTERACTION

被引：23

作者：

SRIVASTAVA, SK ^{[1
]}

DIDONATO, A ^{[1
]}

LACAL, JC ^{[1
]}

机构：

[1] NCI,CELLULAR & MOLEC BIOL LAB,BETHESDA,MD 20892

来源：

MOLECULAR AND CELLULAR BIOLOGY | 1989年 / 9卷 / 04期

关键词：

D O I：

10.1128/MCB.9.4.1779

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：1779 / 1783

页数：5

共 37 条

[1] GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN (GAP) INTERACTS WITH THE P21-RAS EFFECTOR BINDING DOMAIN [J].

ADARI, H ;

LOWY, DR ;

WILLUMSEN, BM ;

DER, CJ ;

MCCORMICK, F .

SCIENCE, 1988, 240 (4851) :518-520

[2] RAS GENES [J].

BARBACID, M .

ANNUAL REVIEW OF BIOCHEMISTRY, 1987, 56 :779-827

[3] THE CYTOPLASMIC PROTEIN GAP IS IMPLICATED AS THE TARGET FOR REGULATION BY THE RAS GENE-PRODUCT [J].

CALES, C ;

HANCOCK, JF ;

MARSHALL, CJ ;

HALL, A .

NATURE, 1988, 332 (6164) :548-551

[4] BIOCHEMICAL-CHARACTERIZATION OF POLYPEPTIDES ENCODED BY MUTATED HUMAN HA-RAS1-GENES [J].

COLBY, WW ;

HAYFLICK, JS ;

CLARK, SG ;

LEVINSON, AD .

MOLECULAR AND CELLULAR BIOLOGY, 1986, 6 (02) :730-734

[5] BIOLOGICAL AND BIOCHEMICAL-PROPERTIES OF HUMAN RASH GENES MUTATED AT CODON-61 [J].

DER, CJ ;

FINKEL, T ;

COOPER, GM .

CELL, 1986, 44 (01) :167-176

[6] 3-DIMENSIONAL STRUCTURE OF AN ONCOGENE PROTEIN - CATALYTIC DOMAIN OF HUMAN C-H-RAS P21 [J].

DEVOS, AM ;

TONG, L ;

MILBURN, MV ;

MATIAS, PM ;

JANCARIK, J ;

NOGUCHI, S ;

NISHIMURA, S ;

MIURA, K ;

OHTSUKA, E ;

KIM, SH .

SCIENCE, 1988, 239 (4842) :888-893

[7] ANALYSIS OF THE TRANSFORMING POTENTIAL OF THE HUMAN H-RAS GENE BY RANDOM MUTAGENESIS [J].

FASANO, O ;

ALDRICH, T ;

TAMANOI, F ;

TAPAROWSKY, E ;

FURTH, M ;

WIGLER, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (13) :4008-4012

[8] MONOCLONAL-ANTIBODIES TO THE P21 PRODUCTS OF THE TRANSFORMING GENE OF HARVEY MURINE SARCOMA-VIRUS AND OF THE CELLULAR RAS GENE FAMILY [J].

FURTH, ME ;

DAVIS, LJ ;

FLEURDELYS, B ;

SCOLNICK, EM .

JOURNAL OF VIROLOGY, 1982, 43 (01) :294-304

[9] BIOCHEMICAL-PROPERTIES OF NORMAL AND ONCOGENIC RAS P21 [J].

GIBBS, JB ;

SIGAL, IS ;

SCOLNICK, EM .

TRENDS IN BIOCHEMICAL SCIENCES, 1985, 10 (09) :350-353

[10] INTRINSIC GTPASE ACTIVITY DISTINGUISHES NORMAL AND ONCOGENIC RAS-P21 MOLECULES [J].

GIBBS, JB ;

SIGAL, IS ;

POE, M ;

SCOLNICK, EM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (18) :5704-5708

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