METHYLMETHACRYLATE IS A MUTAGEN FOR SALMONELLA-TYPHIMURIUM

被引：33

作者：

POSS, R ^{[1
]}

THILLY, WG ^{[1
]}

KADEN, DA ^{[1
]}

机构：

[1] MIT, DEPT NUTR & FOOD SCI, GENET TOXICOL GRP, CAMBRIDGE, MA 02139 USA

来源：

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME | 1979年 / 61卷 / 08期

关键词：

D O I：

10.2106/00004623-197961080-00010

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

The long-term effects of exposure to monomeric methylmethacrylate have yet to be established. We have measured the toxicity and mutagenicity of methylmethacrylate for Salmonella typhimurium. At levels of thirty-four millimolar, methylmethacrylate exhibited 28 per cent of the mutagenic activity of an equimolar dose of dimethylnitrosamine. Methylmethacrylate alone exhibited toxicity to the bacteria, but when the methylacrylate was incubated with a rat-liver enzyme metabolizing system, mutagenesis was induced. These findings suggest that an intermediate metabolite of methylmethacrylate is mutagenic to Salmonella typhimurium.

引用

页码：1203 / 1207

页数：5

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