Persistent polyclonal lymphocytosis has been described in a group of female patients who all have the HLA-DR7 antigen in common and who are all heavy cigarette smokers. Immunoglobulin heavy chain gene rearrangement was analyzed by hybridization with specific immunoglobulin heavy chain genes to restriction enzyme-digested genomic DNA samples. The results in two of these patients showed that the lymphocytosis was associated with an expanded subpopulation of B-lineage cells represented by the presence of an unusual immunoglobulin gene rearrangement pattern. Expansion of this subpopulation of B cells appeared to be linked to cigarette smoking since the intensity of the cell population harboring the rearranged gene was much stronger in patients who were smoking heavily compared with the same patients who were temporarily not smoking.
机构:
HOSP SICK CHILDREN, RES INST, DIV CELL BIOL, TORONTO M5G 1X8, ONTARIO, CANADAHOSP SICK CHILDREN, RES INST, DIV CELL BIOL, TORONTO M5G 1X8, ONTARIO, CANADA
CHEUNG, RK
;
GRINSTEIN, S
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HOSP SICK CHILDREN, RES INST, DIV CELL BIOL, TORONTO M5G 1X8, ONTARIO, CANADAHOSP SICK CHILDREN, RES INST, DIV CELL BIOL, TORONTO M5G 1X8, ONTARIO, CANADA
GRINSTEIN, S
;
GELFAND, EW
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HOSP SICK CHILDREN, RES INST, DIV CELL BIOL, TORONTO M5G 1X8, ONTARIO, CANADAHOSP SICK CHILDREN, RES INST, DIV CELL BIOL, TORONTO M5G 1X8, ONTARIO, CANADA
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INST CANC RES,LEUKAEMIA RES FUND CTR,CHESTER BEATTY LABS,LONDON SW3 6JB,ENGLANDINST CANC RES,LEUKAEMIA RES FUND CTR,CHESTER BEATTY LABS,LONDON SW3 6JB,ENGLAND
MIZUTANI, S
;
FORD, AM
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INST CANC RES,LEUKAEMIA RES FUND CTR,CHESTER BEATTY LABS,LONDON SW3 6JB,ENGLANDINST CANC RES,LEUKAEMIA RES FUND CTR,CHESTER BEATTY LABS,LONDON SW3 6JB,ENGLAND
FORD, AM
;
WIEDEMANN, LM
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INST CANC RES,LEUKAEMIA RES FUND CTR,CHESTER BEATTY LABS,LONDON SW3 6JB,ENGLANDINST CANC RES,LEUKAEMIA RES FUND CTR,CHESTER BEATTY LABS,LONDON SW3 6JB,ENGLAND
WIEDEMANN, LM
;
CHAN, LC
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INST CANC RES,LEUKAEMIA RES FUND CTR,CHESTER BEATTY LABS,LONDON SW3 6JB,ENGLANDINST CANC RES,LEUKAEMIA RES FUND CTR,CHESTER BEATTY LABS,LONDON SW3 6JB,ENGLAND
CHAN, LC
;
FURLEY, AJW
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INST CANC RES,LEUKAEMIA RES FUND CTR,CHESTER BEATTY LABS,LONDON SW3 6JB,ENGLANDINST CANC RES,LEUKAEMIA RES FUND CTR,CHESTER BEATTY LABS,LONDON SW3 6JB,ENGLAND
FURLEY, AJW
;
GREAVES, MF
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INST CANC RES,LEUKAEMIA RES FUND CTR,CHESTER BEATTY LABS,LONDON SW3 6JB,ENGLANDINST CANC RES,LEUKAEMIA RES FUND CTR,CHESTER BEATTY LABS,LONDON SW3 6JB,ENGLAND
GREAVES, MF
;
MOLGAARD, HV
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INST CANC RES,LEUKAEMIA RES FUND CTR,CHESTER BEATTY LABS,LONDON SW3 6JB,ENGLANDINST CANC RES,LEUKAEMIA RES FUND CTR,CHESTER BEATTY LABS,LONDON SW3 6JB,ENGLAND
机构:
HOSP SICK CHILDREN, RES INST, DIV CELL BIOL, TORONTO M5G 1X8, ONTARIO, CANADAHOSP SICK CHILDREN, RES INST, DIV CELL BIOL, TORONTO M5G 1X8, ONTARIO, CANADA
CHEUNG, RK
;
GRINSTEIN, S
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机构:
HOSP SICK CHILDREN, RES INST, DIV CELL BIOL, TORONTO M5G 1X8, ONTARIO, CANADAHOSP SICK CHILDREN, RES INST, DIV CELL BIOL, TORONTO M5G 1X8, ONTARIO, CANADA
GRINSTEIN, S
;
GELFAND, EW
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HOSP SICK CHILDREN, RES INST, DIV CELL BIOL, TORONTO M5G 1X8, ONTARIO, CANADAHOSP SICK CHILDREN, RES INST, DIV CELL BIOL, TORONTO M5G 1X8, ONTARIO, CANADA
机构:
INST CANC RES,LEUKAEMIA RES FUND CTR,CHESTER BEATTY LABS,LONDON SW3 6JB,ENGLANDINST CANC RES,LEUKAEMIA RES FUND CTR,CHESTER BEATTY LABS,LONDON SW3 6JB,ENGLAND
MIZUTANI, S
;
FORD, AM
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INST CANC RES,LEUKAEMIA RES FUND CTR,CHESTER BEATTY LABS,LONDON SW3 6JB,ENGLANDINST CANC RES,LEUKAEMIA RES FUND CTR,CHESTER BEATTY LABS,LONDON SW3 6JB,ENGLAND
FORD, AM
;
WIEDEMANN, LM
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h-index: 0
机构:
INST CANC RES,LEUKAEMIA RES FUND CTR,CHESTER BEATTY LABS,LONDON SW3 6JB,ENGLANDINST CANC RES,LEUKAEMIA RES FUND CTR,CHESTER BEATTY LABS,LONDON SW3 6JB,ENGLAND
WIEDEMANN, LM
;
CHAN, LC
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h-index: 0
机构:
INST CANC RES,LEUKAEMIA RES FUND CTR,CHESTER BEATTY LABS,LONDON SW3 6JB,ENGLANDINST CANC RES,LEUKAEMIA RES FUND CTR,CHESTER BEATTY LABS,LONDON SW3 6JB,ENGLAND
CHAN, LC
;
FURLEY, AJW
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h-index: 0
机构:
INST CANC RES,LEUKAEMIA RES FUND CTR,CHESTER BEATTY LABS,LONDON SW3 6JB,ENGLANDINST CANC RES,LEUKAEMIA RES FUND CTR,CHESTER BEATTY LABS,LONDON SW3 6JB,ENGLAND
FURLEY, AJW
;
GREAVES, MF
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h-index: 0
机构:
INST CANC RES,LEUKAEMIA RES FUND CTR,CHESTER BEATTY LABS,LONDON SW3 6JB,ENGLANDINST CANC RES,LEUKAEMIA RES FUND CTR,CHESTER BEATTY LABS,LONDON SW3 6JB,ENGLAND
GREAVES, MF
;
MOLGAARD, HV
论文数: 0引用数: 0
h-index: 0
机构:
INST CANC RES,LEUKAEMIA RES FUND CTR,CHESTER BEATTY LABS,LONDON SW3 6JB,ENGLANDINST CANC RES,LEUKAEMIA RES FUND CTR,CHESTER BEATTY LABS,LONDON SW3 6JB,ENGLAND