DISTRIBUTION OF PCDDS AND PCDFS IN VARIOUS TISSUES OF MARMOSET MONKEYS

被引：5

作者：

ABRAHAM, K

WIESMULLER, T

HAGENMAIER, H

NEUBERT, D

机构：

[1] FREE UNIV BERLIN,INST TOXIKOL & EMBRYOPHARMAKOL,GARYSTR 5,W-1000 BERLIN 33,GERMANY

[2] UNIV TUBINGEN,INST ORGAN CHEM,W-7400 TUBINGEN 1,GERMANY

来源：

CHEMOSPHERE | 1990年 / 20卷 / 7-9期

关键词：

Marmoset monkeys (Callithrix jacchus); Polychlorinated dibenzo-p-dioxins (PCDDs); Polychlorinated dibenzofurans (PCDFs); Tissue distribution; Toxicokinetics;

D O I：

10.1016/0045-6535(90)90223-G

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

A defined mixture of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDDs and PCDFs) was subcutaneously administered to marmoset monkeys (Callithrix jacchus). Concentrations in different tissues were measured 7 days after treatment. High amounts of the applied dose could be detected for the 2,3,7,8-substituted congeners only. For almost all of these compounds highest concentrations were detected in hepatic and adipose tissue, corresponding values in kidney, brain, lung, heart, thymus or testes were clearly lower. © 1990.

引用

页码：1071 / 1078

页数：8

共 11 条

[1] PHARMACOKINETICS AND BIOLOGICAL-ACTIVITY OF 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN .1. DOSE-DEPENDENT TISSUE DISTRIBUTION AND INDUCTION OF HEPATIC ETHOXYRESORUFIN O-DEETHYLASE IN RATS FOLLOWING A SINGLE INJECTION [J].