POLYMER PROTEIN CONJUGATES .1. EFFECT OF PROTEIN CONJUGATION ON THE CLOUD POINT OF POLY(N-ISOPROPYLACRYLAMIDE)

被引：85

作者：

CHEN, JP ^{[1
]}

YANG, HJ ^{[1
]}

HOFFMAN, AS ^{[1
]}

机构：

[1] UNIV WASHINGTON,CTR BIOENGN,FL-20,SEATTLE,WA 98195

来源：

BIOMATERIALS | 1990年 / 11卷 / 09期

关键词：

polymer-protein conjugates; polymers; Proteins;

D O I：

10.1016/0142-9612(90)90019-M

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Poly(N-isopropylacrylamide) (p(NIPAAm)) exhibits a cloud point around 32°C. In this study we have conjugated several proteins to p(NIPAAm), and the effects of protein molecular weight, pH and ionic strength on the cloud point of the p(NIPAAm)-protein conjugates have been studied. The cloud points of p(NIPAAm)-protein conjugates appear to be unaffected by the molecular weight or isoelectric point (pi) of the proteins, the pH or ionic strength. © 1990.

引用

页码：625 / 630

页数：6

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