MORPHOLOGICAL AND FUNCTIONAL-CHANGES OF ISLETS OF LANGERHANS IN FK506-TREATED RATS

被引：93

作者：

HIRANO, Y

FUJIHIRA, S

OHARA, K

KATSUKI, S

NOGUCHI, H

机构：

[1] Toxicology Research Laboratories, Fujisawa Pharmaceutical Company, Osaka

来源：

TRANSPLANTATION | 1992年 / 53卷 / 04期

关键词：

D O I：

10.1097/00007890-199204000-00033

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

FK506, a new immunosuppressant, caused glucose intolerance in rats given daily oral doses of 1, 5, or 10 mg/kg/day for 14 days, but did not induce hyperglycemia under normal feeding. Besides the glucose intolerance, insulin secretion was impaired and insulin levels in the pancreas were lowered. Histopathologically, there was vacuolation of the Langerhans islets in the animals given 10 mg/kg. After withdrawal of the drug, these changes in pancreatic function and morphology returned to normal within 2 weeks. The findings indicate that FK506 caused dose-dependent but reversible islet toxicity in rats.

引用

页码：889 / 894

页数：6

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