CLONING AND CHARACTERIZATION OF A RECEPTOR-CLASS PHOSPHOTYROSINE PHOSPHATASE GENE EXPRESSED ON CENTRAL-NERVOUS-SYSTEM AXONS IN DROSOPHILA-MELANOGASTER

被引：49

作者：

HARIHARAN, IK

CHUANG, PT

RUBIN, GM

机构：

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1991年 / 88卷 / 24期

关键词：

TYROSINE PHOSPHORYLATION; ONCOGENES; EYE DEVELOPMENT;

D O I：

10.1073/pnas.88.24.11266

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have cloned and characterized cDNAs coding for a receptor-class phosphotyrosine phosphatase gene from Drosophila melanogaster. The gene maps to the polytene chromosome bands 99A7-8. The cDNA clones code for a polypeptide of 1301 amino acids with a predicted molecular mass of 145 kDa. The extracellular domain includes two fibronectin-type III-like domains. The cytoplasmic region contains two tandemly repeated phosphotyrosine phosphatase-like domains. Residues shown crucial for catalytic activity are absent in the second domain. This Drosophila receptor-class phosphotyrosine phosphatase polypeptide is expressed on axons of the embryonic central nervous system.

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页码：11266 / 11270

页数：5

相关论文

共 28 条

[1] BASIC LOCAL ALIGNMENT SEARCH TOOL [J].

ALTSCHUL, SF ;

GISH, W ;

MILLER, W ;

MYERS, EW ;

LIPMAN, DJ .

JOURNAL OF MOLECULAR BIOLOGY, 1990, 215 (03) :403-410

[2] EFFECT ON EYE DEVELOPMENT OF DOMINANT MUTATIONS IN DROSOPHILA HOMOLOG OF THE EGF RECEPTOR [J].

BAKER, NE ;

RUBIN, GM .

NATURE, 1989, 340 (6229) :150-153

[3] SEQUENCE OF AN UNUSUALLY LARGE PROTEIN IMPLICATED IN REGULATION OF MYOSIN ACTIVITY IN C-ELEGANS [J].

BENIAN, GM ;

KIFF, JE ;

NECKELMANN, N ;

MOERMAN, DG ;

WATERSTON, RH .

NATURE, 1989, 342 (6245) :45-50

[4] DROSOPHILA NEUROGLIAN - A MEMBER OF THE IMMUNOGLOBULIN SUPERFAMILY WITH EXTENSIVE HOMOLOGY TO THE VERTEBRATE NEURAL ADHESION MOLECULE L1 [J].

BIEBER, AJ ;

SNOW, PM ;

HORTSCH, M ;

PATEL, NH ;

JACOBS, JR ;

TRAQUINA, ZR ;

SCHILLING, J ;

GOODMAN, CS .

CELL, 1989, 59 (03) :447-460

[5] THE LEUKOCYTE COMMON ANTIGEN (CD45) - A PUTATIVE RECEPTOR-LINKED PROTEIN TYROSINE PHOSPHATASE [J].

CHARBONNEAU, H ;

TONKS, NK ;

WALSH, KA ;

FISCHER, EH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (19) :7182-7186

[6] GENETIC-ANALYSIS OF A DROSOPHILA NEURAL CELL-ADHESION MOLECULE - INTERACTION OF FASCICLIN-I AND ABELSON TYROSINE KINASE MUTATIONS [J].

ELKINS, T ;

ZINN, K ;

MCALLISTER, L ;

HOFFMANN, FM ;

GOODMAN, CS .

CELL, 1990, 60 (04) :565-575

[7] DROSOPHILA ABL TYROSINE KINASE IN EMBRYONIC CNS AXONS - A ROLE IN AXONOGENESIS IS REVEALED THROUGH DOSAGE-SENSITIVE INTERACTIONS WITH DISABLED [J].

GERTLER, FB ;

BENNETT, RL ;

CLARK, MJ ;

HOFFMANN, FM .

CELL, 1989, 58 (01) :103-113

[8] SEVENLESS, A CELL-SPECIFIC HOMEOTIC GENE OF DROSOPHILA, ENCODES A PUTATIVE TRANSMEMBRANE RECEPTOR WITH A TYROSINE KINASE DOMAIN [J].

HAFEN, E ;

BASLER, K ;

EDSTROEM, JE ;

RUBIN, GM .

SCIENCE, 1987, 236 (4797) :55-63

[9] GROWTH CONE GUIDANCE IN INSECTS - FASCICLIN-II IS A MEMBER OF THE IMMUNOGLOBULIN SUPERFAMILY [J].

HARRELSON, AL ;

GOODMAN, CS .

SCIENCE, 1988, 242 (4879) :700-708

[10] PROTEIN-TYROSINE PHOSPHATASES - THE OTHER SIDE OF THE COIN [J].

HUNTER, T .

CELL, 1989, 58 (06) :1013-1016