ABNORMAL STIMULUS-PROCESSING IN POSTTRAUMATIC-STRESS-DISORDER

被引:152
作者
MCFARLANE, AC
WEBER, DL
CLARK, CR
机构
[1] FLINDERS UNIV S AUSTRALIA,SCH PSYCHOL,BOX 2100 GPO,ADELAIDE,SA 5001,AUSTRALIA
[2] UNIV ADELAIDE,DEPT REHABIL PSYCHIAT,ADELAIDE,SA 5001,AUSTRALIA
[3] FLINDERS UNIV S AUSTRALIA,COGNIT NEUROSCI LAB,ADELAIDE,SA 5001,AUSTRALIA
关键词
POSTTRAUMATIC STRESS DISORDER; CONCENTRATION; NORADRENALINE; NEUROTRANSMISSION; EVOKED POTENTIALS; EVENT-RELATED POTENTIALS;
D O I
10.1016/0006-3223(93)90088-U
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
This study investigated event-related potential (EPP) indices of information processing in sufferers of posttraumatic stress disorder (PTSD). ERPs were obtained from 18 PTSD patients and 20 controls while they performed a target discrimination task requiring the detection of infrequent target tones from a background sequence of frequent and infrequent distractor tones. A delayed N2 and an attenuated P3 that failed to differentiate target from distractor tones indicated that patients had abnormal difficulty distinguishing task stimuli of differing relevance. It is proposed that this difficulty is reflected behaviorally in the slowed reaction time by patients to target stimuli and may underlie the disturbed concentration and memory impairments found in PTSD. It may also be related to dysfunction in central noradrenaline function, which has been shown to be both crucial in selective attention and abnormal in PTSD.
引用
收藏
页码:311 / 320
页数:10
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