ACTIVE EFFLUX OF CHLORAMPHENICOL IN SUSCEPTIBLE ESCHERICHIA-COLI STRAINS AND IN MULTIPLE-ANTIBIOTIC-RESISTANT (MAR) MUTANTS

被引：46

作者：

MCMURRY, LM

GEORGE, AM

LEVY, SB

机构：

[1] TUFTS UNIV,SCH MED,CTR ADAPTAT GENET,BOSTON,MA 02111

[2] TUFTS UNIV,SCH MED,DEPT MICROBIOL,BOSTON,MA 02111

[3] TUFTS UNIV,SCH MED,DEPT MED,BOSTON,MA 02111

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1994年 / 38卷 / 03期

关键词：

D O I：

10.1128/AAC.38.3.542

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The multiple-antibiotic resistance (mar) locus (min 34) regulates a resistance to chloramphenicol in Escherichia coli that does not involve acetyltransferase. Transport studies showed that wild-type cells had an apparent endogenous active efflux of chloramphenicol which depended on the proton motive force. This efflux was not altered by a 39-kb chromosomal deletion which included the mar locus. Nevertheless, mutations at the mar locus led to a stronger net chloramphenicol efflux. Therefore, a gene encoding the putative efflux system cannot be at the mar locus but may be positively influenced by that locus.

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页码：542 / 546

页数：5

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