IDENTIFICATION AND EXPRESSION OF G-PROTEINS IN HUMAN MYOMETRIUM - UP-REGULATION OF G-ALPHA-S IN PREGNANCY

被引：90

作者：

EUROPEFINNER, GN ^{[1
]}

PHANEUF, S ^{[1
]}

WATSON, SP ^{[1
]}

BERNAL, AL ^{[1
]}

机构：

[1] DEPT PHARMACOL, OXFORD OX1 3QT, ENGLAND

来源：

ENDOCRINOLOGY | 1993年 / 132卷 / 06期

关键词：

D O I：

10.1210/en.132.6.2484

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report that human myometrium contains Galpha(i1), Galpha(i3), Galpha(q), and Galpha11, which are expressed at similar levels in tissues from pregnant and nonpregnant women. Galpha(i2) is also expressed, but at a slightly reduced level, in tissue taken from pregnant compared to nonpregnant donors. The major finding of this investigation is the substantial increase in Galpha(s) expression in pregnant myometrium. The increase in Galpha(s) levels may play a crucial role in maintaining relaxation of the uterus by favoring cAMP formation during pregnancy.

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页码：2484 / 2490

页数：7

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