BROMODEOXYURIDINE-LABELED APOPTOSIS AFTER TREATMENT WITH ANTIMETABOLITES IN 2 MURINE TUMORS AND IN SMALL-INTESTINAL CRYPTS

被引：24

作者：

SARRAF, CE ^{[1
]}

ANSARI, TW ^{[1
]}

CONWAY, P ^{[1
]}

NOTAY, M ^{[1
]}

HILL, S ^{[1
]}

ALISON, MR ^{[1
]}

机构：

[1] MT VERNON HOSP,CANC RES CAMPAIGN,GRAY LAB,NORTHWOOD HA6 2RN,MIDDX,ENGLAND

来源：

BRITISH JOURNAL OF CANCER | 1993年 / 68卷 / 04期

关键词：

D O I：

10.1038/bjc.1993.408

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Antimetabolites are S-phase specific anticancer drugs. Administration of bromodeoxyuridine (BrdUrd) to tumour bearing mice was followed by treatment with cytosine arabinoside or hydroxyurea. Anti-BrdUrd immunocytochemistry visualised susceptible tumour and intestinal crypt cells at electron microscope level, showing unequivocally that cells that were in S-phase at the time of administration of the drugs subsequently died by apoptosis.

引用

页码：678 / 680

页数：3

共 13 条

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