Phosphorylatioti of transcriptional factors and cell-cycle-dependent proteins by casein kinase II
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作者:
Meisner, Herman
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Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA
Univ Massachusetts, Sch Med, Dept Biochem & Mol Biol, Worcester, MA 10605 USAUniv Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA
Meisner, Herman
[1
,2
]
Czech, Michael P.
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Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA
Univ Massachusetts, Sch Med, Dept Biochem & Mol Biol, Worcester, MA 10605 USAUniv Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA
Czech, Michael P.
[1
,2
]
机构:
[1] Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA
[2] Univ Massachusetts, Sch Med, Dept Biochem & Mol Biol, Worcester, MA 10605 USA
Casein kinase II is involved in the phosphorylation of several proto-oncogenes, anti-oncogenes, and oncogenes that are nuclear transcriptional regulatory factors. The potential functions of the phosphorylations in each of these proteins are evaluated. New findings indicate that casein kinase II is a critical component of the mechanisms regulating the cell cycle.