D-FENFLURAMINE AND D-NORFENFLURAMINE HYPOPHAGIAS DO NOT REQUIRE INCREASED HYPOTHALAMIC 5-HYDROXYTRYPTAMINE RELEASE

被引：38

作者：

OLUYOMI, AO ^{[1
]}

GIBSON, EL ^{[1
]}

BARNFIELD, AMC ^{[1
]}

CURZON, G ^{[1
]}

机构：

[1] INST NEUROL,DEPT NEUROCHEM,LONDON WC1N 3BG,ENGLAND

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1994年 / 264卷 / 01期

关键词：

FOOD INTAKE; D-FENFLURAMINE; D-NORFENFLURAMINE; MICRODIALYSIS; P-CHLOROPHENYLALANINE;

D O I：

10.1016/0014-2999(94)90646-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

d-Fenfluramine (2.5 mg/kg i.p.) caused marked hypophagia in food-deprived rats and significantly increased medial hypothalamic extracellular 5-hydroxytryptamine (5-HT) as indicated by in vivo microdialysis. When the drug was given after the 5-HT synthesis inhibitor p-chlorophenylalanine (150 mg/kg per day X 3) the hypophagic response was unimpaired but dialysate 5-HT concentration no longer rose. The d-fenfluramine metabolite d-norfenfluramine (1.5 mg/kg i.p.) caused slightly greater hypophagia than the parent drug and completely blocked feeding in animals pretreated with p-chlorophenylalanine, but dialysate 5-HT was increased in neither circumstance. The results provide evidence against mediation of the hypophagic effects of d-fenfluramine and d-norfenfluramine by increased availability of 5-HT to receptors.

引用

页码：111 / 115

页数：5

共 14 条

[1] SUPPRESSION OF BEHAVIORAL ACTIVITY BY NORFENFLURAMINE AND RELATED DRUGS IN RATS IS NOT MEDIATED BY SEROTONIN RELEASE [J].