HEPATOPROTECTIVE EFFECTS OF PROPOLIS EXTRACT ON CARBON TETRACHLORIDE-INDUCED LIVER-INJURY IN RATS

被引：50

作者：

GONZALEZ, R

CORCHO, I

REMIREZ, D

RODRIGUEZ, S

ANCHETA, O

MERINO, N

GONZALEZ, A

PASCUAL, C

机构：

[1] Department of Pharmacology, National Center for Scientific Research, Havana

来源：

PHYTOTHERAPY RESEARCH | 1995年 / 9卷 / 02期

关键词：

PROPOLIS; PREVENTION; CARBON TETRACHLORIDE; HEPATOTOXICITY;

D O I：

10.1002/ptr.2650090207

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The effects of an ethanolic extract of Cuban red propolis were examined using the model of acute hepatotoxicity induced by carbon tetrachloride (CCL(4)) in rats. Propolis extract at doses of 5, 10 and 25 mg/kg i.p. decreased significantly the activity of alanine aminotransferase and the concentration of malondialdehyde in rat serum as well as the concentration of triglycerides in liver which were increased in CCl4-treated animals. An ethanol extract of red propolis also reduced liver damage induced by CCL(4)in rats. This effect was observed by electron microscopy. According to our results it is concluded that ethanolic extract of red propolis exerts hepatoprotective effects in this experimental model which are probably caused by antioxidative properties (e.g, scavenging action against oxygen radicals) of this extract.

引用

页码：114 / 117

页数：4

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