INDUCTION OF RETINOID RESISTANCE BY ALL-TRANS-RETINOIC ACID IN ACUTE PROMYELOCYTIC LEUKEMIA AFTER REMISSION

被引:16
作者
CORNIC, M
CHOMIENNE, C
机构
[1] Laboratoire de: Biologie Cellulaire Hématopoiétique, Institut d'Hematologie Hôpital, Saint-Louis 75010, Paris
关键词
RETINOID RESISTANCE; ALL-TRANS RETINOIC ACID; ACUTE PROMYELOCYTIC LEUKEMIA; APL; REMISSION;
D O I
10.3109/10428199509059615
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Acute promyelocytic leukemia (APL) results from a malignant process that leads to the accumulation in the blood and the bone marrow of myeloid precursor cells characterized by an abnormal behavior and a differentiation arrest. It aroused considerable interest well beyond the hematologic field during the last five years since APL has two unique features i) the remission of the disease obtained with all-trans retinoic acid (ATRA) treatment ii) the presence in APL blasts of an abnormal protein, the promyelocytic myeloid leukemia/retinoic acid receptor (PML/RAR alpha) protein, APL is characterized cytogenetically by a t(15;17) translocation which involves both the PML gene on chromosome 15 and the RAR alpha gene on chromosome 17 and gives rise to the PML/RAR alpha fusion protein.
引用
收藏
页码:249 / 257
页数:9
相关论文
共 114 条
[1]  
Huang M.E., Ye Y.I., Chen S.R., Chai J.R., Lu J.X., Zhoa L., Gu L.J., Wang Z.Y., Use of all-trans-retinoic acid in the treatment of acute promyelocytic leukemia, Blood, 72, pp. 567-571, (1988)
[2]  
Castaiene S., Chomienne C., Daniel M.T., Fenaux P., Berger R., Degos L., All-trans retinoic acid as a differentiation therapy in acute promyelocytic leukemias, I. Clinicals results, Blood, 76, pp. 1704-1707, (1990)
[3]  
Warrel R.P., Frankel S.R., Miller W.H., Scheinberg D.A., Itri L.M., Hittelman W.N., Vyas R., Andreff A., Tafudi A., Jakubowski A., Gabrilove J., Gordon M., Dmitrovsky E., Differentiation therapy of acute promyelocytic leukemia with tretinoin (all-trans retinoic acid), N. Engl, J. Med., 324, pp. 1385-1393, (1991)
[4]  
Sun G.L., Huang Chang Y.G., Jiang G.S., Zhang T., Clinical study on all-trans retinoic acid in treatment of 544 cases of acute promyelocytic leukemia treated, Chin, J. Hematol., 13, pp. 135-137, (1992)
[5]  
Borrow J., Goddard A.D., Sheer D., Solomon E., Molecular analysis of APL breakpoint of acute promyelocytic leukemia lies within the retinoic acid receptor alpha gene to a novel transcribed locus, Science, 249, pp. 1577-1580, (1990)
[6]  
de The Chomienne H.C., Lanotte M., Degos L., Dejean A., The t(15
[7]  
17) translocation of acute promyelocytic leukemia fuses the retinoic acid receptor-alpha gene to a novel transcribed locus, Nature, 347, pp. 558-561, (1990)
[8]  
Longo L., Pantolfi P.P., Biondi P., Biondi A., Rambaldi A., Mencarelli A., Lo C.O.C., O F., Diverio D., Pegoraro C., Avanzi G., Tabilio A., Donti E., Grignani F., Pellici P.G., Rearrangement and aberrant expression of the retinoic acid receptor alpha gene in acute promyelocytic leukemia, J. Exp. Med., 172, pp. 1571-1575, (1990)
[9]  
Wolbach S.B., Howe P.R., Tissue changes following deprivation of fat soluble A vitamin, J. Exp. Med., 42, pp. 753-777, (1925)
[10]  
Osborne T.B., Mendel L.B., The relation of growth to the chemical constituents of the diet, J. Biol. Chem., 15, pp. 311-326, (1913)