ANTITUMOR POTENTIAL OF POLLEN EXTRACT ON LEWIS-LUNG-CARCINOMA IMPLANTED INTRAPERITONEALLY IN SYNGENEIC MICE

被引：17

作者：

FURUSAWA, E ^{[1
]}

CHOU, SC ^{[1
]}

HIRAZUMI, A ^{[1
]}

MELERA, A ^{[1
]}

机构：

[1] SAPEC SA,BARBENGO,SWITZERLAND

来源：

PHYTOTHERAPY RESEARCH | 1995年 / 9卷 / 04期

关键词：

ANTITUMOR; POLLEN EXTRACT; MURINE LUNG TUMOR; IMMUNOMODULATOR;

D O I：

10.1002/ptr.2650090405

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

A defined pollen extract of selected plants has been reported to possess some pharmacological activities on chronic prostatis or benign prostatic hyperplasia. This paper describes the antitumour potential of the water-soluble fraction (Cernitin T60) of pollen extract against Lewis lung carcinoma implanted intraperitoneally in syngeneic mice. Cernitin T60 was not cytotoxic in cell cultures at concentrations up to 2.5 mg/mL, while it is significantly prolonged the life-span of mice carrying the tumour without any apparent side effects at 0.5 g/kg. In addition, Cernitin T60 demonstrated beneficial therapeutic effects in an additive fashion on the life-span of mice when it was combined with standard cytotoxic antitumour drugs such as adriamycin, cisplatin, vincristine, methotrexate, fluorouracil, or thioguanine. The antitumour potential of Cernitin T60 was completely abolished by treatment with inhibitors of macrophage functions (2-chloroadenosine or carrageenan), but not with a T-cell inhibitor (cyclosporin A). Cernitin T60 appears to be a potent immunostimulator of macrophages.

引用

页码：255 / 259

页数：5

共 26 条

[1]

Buck A.C., Cox R., Rees W.M., Ebeling L., John A., Treatment of outflow tract obstruction due to benign prostatic hyperplasia with the pollen extract, Cernilton, a double‐blind, placebo‐controlled study, Br. J. Urol., 66, pp. 398-404, (1990)

[2]

Buck A.C., Rees W.M., Ebeling L., Treatment of chronic prostatis and prostatodynia with pollen extract, Br. J. Urol., 64, pp. 496-499, (1989)

[3]

Ceglecka M., Wojcicki J., Gonet B., Put A., Kuzna-Grygiel W., Samochowiec L., Effect of pollen extracts on prolonged poisoning of rats with organic solvents, Phytocher. Res., 5, pp. 245-249, (1991)

[4]

DiPadova F.E., Pharmacology of cyclosporine (Sandimmune) V. Pharmacological effects on immune function: in vitro studies, Pharmacol. Rev., 41, pp. 373-405, (1989)

[5]

Ebeling L., pp. 154-160, (1986)

[6]

Furusawa E., Chou S.C., Furusawa S., Hirazumi A., Dang Y., Antitumour activity of Ganoderma lucidum, an edible mushroom, on intraperitoneally implanted Lewis lung carcinoma in syngeneic mice, Phytother. Res., 6, pp. 300-304, (1992)

[7]

Furusawa E., Furusawa S., Antitumor activity of a natural product, Viva‐Natural, extracted from Undaria pinantifida on intraperitoneally implanted Lewis lung carcinoma, Oncology, 42, pp. 364-369, (1985)

[8]

Furusawa E., Furusawa S., Anticancer potential of Viva‐Natural, a dietary seaweed extract, on Lewis lung carcinoma in comparison with chemical immunomodulators and on cyclosporine‐accelerated AKR leukemia, Oncology, 46, pp. 343-349, (1989)

[9]

Furusawa E., Furusawa S., Antitumor potential of low‐dose chemotherapy manifested in combination with immunortherapy of Viva‐Natural, a dietary seaweed extract, on Lewis lung carcinoma, Cancer Lett., 50, pp. 71-78, (1990)

[10]

Goldin A., Venditti J.M., Carter S.K., Protocols for in vivo screening systems and for in vitro KB cell culture screen, National Cancer Institute Monograph, 45, pp. 147-150, (1977)

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