AFFINITY OF HUMAN-LEUKOCYTE INTERFERON FOR POLYRIBONUCLEOTIDES

被引：1

作者：

CHADHA, KC

GROB, PM

机构：

[1] Roswell Park Memorial Institute Viral Oncology Department Buffalo

来源：

CELL BIOLOGY INTERNATIONAL REPORTS | 1979年 / 3卷 / 08期

关键词：

D O I：

10.1016/0309-1651(79)90097-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Human leukocyte interferon (HL-IF) binds to AGPOLY(A)™, AGPOLY(U)™ and AGPOLY(I)™. The bound interferon could be displaced from all three polyribonucleotides by including sodium chloride in the eluant. The nature of interaction of HL-IF with polyribonucleotides is electrostatic and not hydrophobic since its binding was not prevented in the presence of 50% ethylene glycol. The binding of HL-IF on AGPOLY(I)™ is stronger at lower pH since an increase in ionic strength is required to displace it. © 1979.

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页码：663 / 669

页数：7

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