METABOLISM OF OXIDIZED LINOLEIC-ACID - DISTRIBUTION OF ACTIVITY FOR THE ENZYMATIC OXIDATION OF 13-HYDROXYOCTADECADIENOIC ACID TO 13-OXOOCTADECADIENOIC ACID IN RAT-TISSUES

被引：23

作者：

BULL, AW

EARLES, SM

BRONSTEIN, JC

机构：

[1] Department of Chemistry, Oakland University, Rochester

来源：

PROSTAGLANDINS | 1991年 / 41卷 / 01期

关键词：

D O I：

10.1016/0090-6980(91)90103-M

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Oxidation products of linoleic acid, including hydroperoxy- and hydroxyoctadecadienoic acids have been shown to possess biological activities in a number of different systems. In this work we describe an enzymatic activity which catalyzes the conversion of 13-hydroxyoctadecadienoic acid to a widely distributed, with the highest activity in the colon and the liver. The distribution of activity among various tissues is distinct from other dehydrogenases known to use oxygenated unsaturated fatty acids as substrates. This enzyme may play a key role in the metabolism of 13-hydroxyoctadecadienoic acid in epithelial tissues.

引用

页码：43 / 50

页数：8

共 12 条

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