DEVELOPMENT OF 4-ALKYLPHENYL ARALKYL ETHERS AND RELATED-COMPOUNDS AS POTENT INSECT JUVENILE-HORMONE MIMETICS AND STRUCTURAL ASPECTS OF THEIR ACTIVITY

We prepared as insect juvenile hormone mimetics 4-alkylphenyl phenylalkyl and phenoxyalkyl ethers and corresponding pyridine derivatives, in which the oxime moiety of the (4-alkylphenoxy)- alkanaldoxime O-ethers we have already developed is replaced by an aromatic function. The activity, examined against Culex pipiens, of the most potent member was comparable to that of the most active JH mimetics so far known. Their structure-activity profiles were compared with those of the previous, nonaromatic ethers, oximes, and related compounds to make the features characteristic to the aromatic function apparent. © 1990, American Chemical Society. All rights reserved.