CHEMICAL-STIMULATION OF THE NUCLEUS LOCUS-CERULEUS - CARDIOVASCULAR-RESPONSES AND BAROREFLEX MODIFICATION

被引：27

作者：

MURASE, S ^{[1
]}

TAKAYAMA, M ^{[1
]}

NOSAKA, S ^{[1
]}

机构：

[1] MIE UNIV,SCH MED,DEPT PSYCHIAT,TSU,MIE 514,JAPAN

来源：

NEUROSCIENCE LETTERS | 1993年 / 153卷 / 01期

关键词：

AORTIC DEPRESSOR NERVE; BAROREFLEX; GLUTAMATE; HOMOCYSTEIC ACID; LOCUS-CERULEUS; NUCLEUS-TRACTUS-SOLITARIUS;

D O I：

10.1016/0304-3940(93)90062-P

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Microinjection of glutamate (Glu, 2.5 nmol) or homocysteic acid (HA, 0.1-0.5 nmol) into the nucleus locus coeruleus (LC) decreased both blood pressure and heart rate. These microinjections also produced a facilitatory or occlusive effect on depressor and bradycardiac responses evoked by electrical stimulation of the aortic depressor nerve (ADN). Destruction of the nucleus tractus solitarius (NTS), which totally eliminated ADN-evoked responses, had no effect on the cardiovascular responses evoked by LC stimulation. These results suggest that the neuronal populations that contribute to the LC-induced cardiovascular responses overlap at least partly with the baroreflex substrate other than the NTS.

引用

页码：1 / 4

页数：4

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