A COMPARATIVE-STUDY OF LIVER MIXED-FUNCTION OXIDASES IN CAMELS (CAMELUS-DROMEDARIUS), GUINEA-PIGS (CAVIA-PORCELLUS) AND RATS (RATTUS-NORVEGICUS)

被引：5

作者：

DAMANHOURI, ZA ^{[1
]}

TAYEB, OS ^{[1
]}

机构：

[1] KING ABDULAZIZ UNIV,FAC MED & ALLIED SCI,KING FAHAD MED RES CTR,DEPT PHARMACOL,DRUG METAB UNIT,JEDDAH 21413,SAUDI ARABIA

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY | 1993年 / 105卷 / 03期

关键词：

D O I：

10.1016/0742-8413(93)90090-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. The activities of the drug-metabolizing enzymes, benzphetamine N-demethylase, 7-ethoxy-coumarin O-deethylase and dicoumarol oxidation have been measured in vitro in the liver of camels, guinea pigs and rats. 2. In these species, levels of hepatic microsomal parameters namely microsomal protein, cytochrome P450, cytochrome b5 and NADPH-cytochrome c reductase have also been determined. 3. In general, camels seemed to have the lowest enzyme activity when compared to rats and guinea pigs. 4. Some sex differences were observed in the levels of enzymes studied. In rats and guinea pigs, males had higher benzphetamine N-demethylase than females. However, in camels and guinea pigs, females had higher 7-ethoxycoumarin O-deethylase when compared to males.

引用

页码：487 / 491

页数：5

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