TRANSTHYRETIN EXPRESSION EVOLVED MORE RECENTLY IN LIVER THAN IN BRAIN

被引：33

作者：

SCHREIBER, G ^{[1
]}

PETTERSSON, TM ^{[1
]}

SOUTHWELL, BR ^{[1
]}

ALDRED, AR ^{[1
]}

HARMS, PJ ^{[1
]}

RICHARDSON, SJ ^{[1
]}

WETTENHALL, REH ^{[1
]}

WEI, D ^{[1
]}

NICOL, SC ^{[1
]}

机构：

[1] UNIV TASMANIA,DEPT PHYSIOL,HOBART,TAS 7001,AUSTRALIA

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY | 1993年 / 105卷 / 02期

关键词：

D O I：

10.1016/0305-0491(93)90235-W

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. Transthyretin was found to be synthesized and secreted by choroid plexus from rats, echidnas, and lizards, but not toads. 2. Transthyretin was observed in blood from placental mammals, birds, and marsupials, but not reptiles and monotremes. 3. The obtained data suggest that transthyretin synthesis by the liver evolved independently in the lineage leading to the placental mammals and marsupials and in that leading to the birds. 4. It is proposed that transthyretin gene expression in mammalian liver appeared about 200 million years later than its first occurrence in the choroid plexus of the stem reptiles.

引用

页码：317 / 325

页数：9

共 48 条

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