PRESSURE-INDUCED DISORDERS IN NEUROTRANSMISSION AND SPONTANEOUS BEHAVIOR IN RATS - AN ANIMAL-MODEL OF PSYCHOSIS

被引：9

作者：

ABRAINI, JH ^{[1
]}

ANSSEAU, M ^{[1
]}

FECHTALI, T ^{[1
]}

机构：

[1] CHU SART TILMAN,UNITE NEUROPSYCHIAT,LIEGE,BELGIUM

来源：

BIOLOGICAL PSYCHIATRY | 1993年 / 34卷 / 09期

关键词：

SCHIZOPHRENIA; ANIMAL MODEL; HIGH PRESSURE; DOPAMINE; AMINO ACIDS;

D O I：

10.1016/0006-3223(93)90154-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Disorders in neurotransmission and spontaneous behavior in rats exposed to a high pressure helium-oxygen mixture that shows interesting parallels with the dopaminergic hypothesis of schizophrenia at both the biochemical and the therapeutic responding levels are reviewed. Furthermore, as human subjects exposed to a very high pressure have shown psychotic episodes, we conclude that the pressure-induced disorders in neurotransmission and spontaneous behavior in rats could constitute a valid animal model of schizophreniform psychosis and a useful tool for both the investigation of the biological mechanisms underlying schizophrenia and the development of new antipsychotic drugs.

引用

页码：622 / 629

页数：8

共 49 条

[1] PRESSURE-INDUCED STRIATAL DOPAMINE RELEASE CORRELATES HYPERLOCOMOTOR ACTIVITY IN RATS EXPOSED TO HIGH-PRESSURE [J].