HEPARINIZATION OF BIOLOGICAL VASCULAR GRAFT REDUCES FIBRIN DEPOSITION

被引:5
作者
BOERBOOM, LE
OLINGER, GN
KARAS, BJ
LINDON, JN
ROSEN, LZ
THYAGARAJAN, K
TU, R
机构
[1] BAXTER HLTH CARE CORP, DIV APPL SCI, IRVINE, CA USA
[2] BAXTER HLTH CARE CORP, EDWARDS DIV, IRVINE, CA USA
关键词
BLOOD VESSEL PROSTHESIS; CORONARY ARTERY BYPASS GRAFT; DENAFLEX; BIOFLOW; HEPARIN; THROMBOSIS;
D O I
10.1177/039139889301600506
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
An alternative graft is needed for coronary bypass operations in patients lacking suitable autologous vessels. We therefore studied Denaflex(TM) a biologic graft, in a dog ex-vivo shunt model to determine whether heparin treatment makes this graft less thrombogenic. Comparison was also made to Bioflow(TM) a nonheparinized biologic graft. Fibrinogen deposition during high flow (593 +/- 202 ml/min) decreased from 672 +/- 467 ng/mm2 in nonheparinized Denaflex grafts to 448 +/- 298 ng/mm2 (p<0.05) in heparinized Denaflex grafts. At low now (117 +/- 13 ml/min), heparinization of Denaflex grafts similarly decreased fibrinogen deposition from 1102 +/- 601 ng/mm2 to 703 +/- 405 ng/mm2 (p<0.05). At both flow rates fibrinogen deposition in Bioflow grafts was less than in nonheparinized Denaflex, but was similar to heparinized Denaflex grafts. Platelet deposition was not influenced by heparinization of Denaflex grafts and was similar among Denaflex and Bioflow preparations. Whether Denaflex performs acceptably in vivo as a xenograft requires extensive study.
引用
收藏
页码:263 / 267
页数:5
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