PREPARATION AND CHARACTERIZATION OF LECTIN-LATEX CONJUGATES FOR SPECIFIC BIOADHESION

被引：58

作者：

IRACHE, JM ^{[1
]}

DURRER, C ^{[1
]}

DUCHENE, D ^{[1
]}

PONCHEL, G ^{[1
]}

机构：

[1] UNIV PARIS SUD,PHARM GALEN & BIOPHARM LAB,CNRS,URA 1218,F-92296 CHATENAY MALABRY,FRANCE

来源：

BIOMATERIALS | 1994年 / 15卷 / 11期

关键词：

LECTIN; BIOADHESION; LATEX; NANOPARTICLES; MUCIN;

D O I：

10.1016/0142-9612(94)90114-7

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

This paper reports on the preparation and characterization of certain bioadhesive model drug delivery systems formed by a carrier (e.g. modified nanoparticles of polystyrene) and a ligand (e.g. tomato lectin, asparagus pea lectin, Mycoplasma gallisepticum lectin or albumin). Three different manufacturing methods (carbodiimide and glutaraldehyde coupling and physical adsorption) were studied. The activity of the lectin-latex conjugates and albumin-latex conjugate (control) were tested with gastric pig mucin. The manufacturing method had an insignificant effect on the activity, but all lectin-latex conjugates interacted two or three times more with mucin than with the control.

引用

页码：899 / 904

页数：6

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