DISTINCT REGULATION OF SODIUM-CHANNEL TYPE-I, TYPE-II AND TYPE-III FOLLOWING NERVE TRANSECTION

被引：42

作者：

IWAHASHI, Y

FURUYAMA, T

INAGAKI, S

MORITA, Y

TAKAGI, H

机构：

[1] OSAKA CITY UNIV,SCH MED,DEPT ANAT 1,ABENO KU,OSAKA 545,JAPAN

[2] SUNTORY LTD,INST BIOMED RES,OSAKA 618,JAPAN

来源：

MOLECULAR BRAIN RESEARCH | 1994年 / 22卷 / 1-4期

关键词：

SODIUM CHANNEL; SODIUM CHANNEL TYPE I; SODIUM CHANNEL TYPE II; SODIUM CHANNEL TYPE III; BRAIN; FACIAL NUCLEUS; MOTOR NEURON; NERVE TRANSECTION; IN SITU HYBRIDIZATION;

D O I：

10.1016/0169-328X(94)90064-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated mRNA expression of type I, II and III voltage-sensitive sodium channels in motoneurons following facial nerve transection by means of in situ hybridization histochemistry. Type I mRNA expression decreased markedly after nerve transection, while that of type III increased. Type II expression underwent no detectable change following nerve transection. These results suggest that type III sodium channels may be involved in regeneration and plasticity.

引用

收藏

页码：341 / 345

页数：5

相关论文

共 13 条

[1] A RAT-BRAIN NA+ CHANNEL ALPHA-SUBUNIT WITH NOVEL GATING PROPERTIES [J].

AULD, VJ ;

GOLDIN, AL ;

KRAFTE, DS ;

MARSHALL, J ;

DUNN, JM ;

CATTERALL, WA ;

LESTER, HA ;

DAVIDSON, N ;

DUNN, RJ .

NEURON, 1988, 1 (06) :449-461

[2] DIFFERENTIAL REGULATION OF 3 SODIUM-CHANNEL MESSENGER-RNAS IN THE RAT CENTRAL NERVOUS-SYSTEM DURING DEVELOPMENT [J].

BECKH, S ;

NODA, M ;

LUBBERT, H ;

NUMA, S .

EMBO JOURNAL, 1989, 8 (12) :3611-3616

[3] EXPRESSION OF NERVE GROWTH-FACTOR RECEPTOR MESSENGER-RNA IS DEVELOPMENTALLY REGULATED AND INCREASED AFTER AXOTOMY IN RAT SPINAL-CORD MOTONEURONS [J].

ERNFORS, P ;

HENSCHEN, A ;

OLSON, L ;

PERSSON, H .

NEURON, 1989, 2 (06) :1605-1613

[4] DISTRIBUTION OF I, II AND III SUBTYPES OF VOLTAGE-SENSITIVE NA+ CHANNEL MESSENGER-RNA IN THE RAT-BRAIN [J].

FURUYAMA, T ;

MORITA, Y ;

INAGAKI, S ;

TAKAGI, H .

MOLECULAR BRAIN RESEARCH, 1993, 17 (1-2) :169-173

[5]

FURUYAMA T, 1993, NEUROSCI RES S, V17, pS172

[6] PRIMARY STRUCTURE OF RAT-BRAIN SODIUM CHANNEL-III DEDUCED FROM THE CDNA SEQUENCE [J].

KAYANO, T ;

NODA, M ;

FLOCKERZI, V ;

TAKAHASHI, H ;

NUMA, S .

FEBS LETTERS, 1988, 228 (01) :187-194

[7] LOCALIZATION OF NERVE GROWTH-FACTOR RECEPTOR MESSENGER-RNA AND PROTEIN IN THE ADULT-RAT BRAIN [J].

KOH, S ;

OYLER, GA ;

HIGGINS, GA .

EXPERIMENTAL NEUROLOGY, 1989, 106 (03) :209-221

[8] EXISTENCE OF DISTINCT SODIUM-CHANNEL MESSENGER-RNAS IN RAT-BRAIN [J].

NODA, M ;

IKEDA, T ;

KAYANO, T ;

SUZUKI, H ;

TAKESHIMA, H ;

KURASAKI, M ;

TAKAHASHI, H ;

NUMA, S .

NATURE, 1986, 320 (6058) :188-192

[9]

RICHARDSON PM, 1986, J NEUROSCI, V6, P2312

[10] EFFECTS OF NERVE CRUSH AND TRANSECTION ON MESSENGER-RNA LEVELS FOR NERVE GROWTH-FACTOR RECEPTOR IN THE RAT FACIAL MOTONEURONS [J].

SAIKA, T ;

SENBA, E ;

NOGUCHI, K ;

SATO, M ;

YOSHIDA, S ;

KUBO, T ;

MATSUNAGA, T ;

TOHYAMA, M .

MOLECULAR BRAIN RESEARCH, 1991, 9 (1-2) :157-160