MITOGENIC EFFECT OF A GROWTH-FACTOR DERIVED FROM MYELIN ON DENERVATED REGENERATES OF NEWT FORELIMBS

被引：54

作者：

MESCHER, AL ^{[1
]}

GOSPODAROWICZ, D ^{[1
]}

机构：

[1] SALK INST BIOL STUDIES,LA JOLLA,CA 92037

来源：

JOURNAL OF EXPERIMENTAL ZOOLOGY | 1979年 / 207卷 / 03期

关键词：

D O I：

10.1002/jez.1402070318

中图分类号：

Q95 [动物学];

学科分类号：

071002 ;

摘要：

Fibroblast growth factor injected into denervated early regenerates of adult newt forelimbs promotes mitotic activity in the dedifferentiated mesodermal cells. The effect is dose‐dependent and is not produced with similar doses of cytochrome c, bovine serum albumin, or growth hormone. Epidermal growth factor has a mitogenic effect less than half as great as that of fibroblast growth factor. The results suggest the possibility of a role for myel in‐derived growth factors in blastema formation. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：497 / 503

页数：7

共 23 条

[1] NERVE TROPHIC EFFECTS - INVITRO ASSAY FOR FACTORS INVOLVED IN REGULATION OF PROTEIN-SYNTHESIS IN REGENERATING AMPHIBIAN LIMBS [J].