SYNTHESIS OF A PROPOSED THYMIC FACTOR

被引：21

作者：

STRACHAN, RG ^{[1
]}

PALEVEDA, WJ ^{[1
]}

BERGSTRAND, SJ ^{[1
]}

NUTT, RF ^{[1
]}

HOLLY, FW ^{[1
]}

VEBER, DF ^{[1
]}

机构：

[1] MERCK SHARP & DOHME,RES LABS,W POINT,PA 19486

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1979年 / 22卷 / 05期

关键词：

D O I：

10.1021/jm00191a026

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

<Glu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn, a proposed serum thymic factor, has been synthesized. The protected precursor, <Glu-Ala-Lys((-Noc)-Ser(Bzl)-Gln-Gly-Gly-Ser(Bzl)-Asn, was prepared by a combination of solid phase and solution methods. The benzyl blocking groups were removed by HF and the i-Noc blocking group was removed by catalytic hydrogenation. © 1979, American Chemical Society. All rights reserved.

引用

页码：586 / 588

页数：3

共 13 条

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