COMPARISON OF NORMAL SUB-MAXILLARY GLAND PROTEINS WITH PROTEINS OBTAINED FROM A TRANSPLANTABLE MURINE SALIVARY-GLAND CARCINOMA (MYOEPITHELIOMA)

被引：1

作者：

IRWIN, D ^{[1
]}

MALAMUD, D ^{[1
]}

机构：

[1] UNIV PENN, SCH DENT MED, DEPT BIOCHEM, PHILADELPHIA, PA 19104 USA

来源：

CELL BIOLOGY INTERNATIONAL REPORTS | 1979年 / 3卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0309-1651(79)90071-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A new transplantable murine salivary gland carcinoma (myoepithelioma) was further characterized by comparing total protein patterns with normal submaxillary qland proteins. Analysis by isoelectric focussing or by labelling studies with radioactive leucine showed considerable differences between tumour and normal proteins. In contrast, analysis of staining patterns after electrophoresis in sodium dodecyl sulphate containing gels revealed a striking similarity between normal proteins, tumour proteins and proteins obtained from metastatic growths. It thus appears that tumour proteins closely resemble the normal proteins from the tissue of origin with respect to molecular size as determined by electrophoretic mobility, while significant differences occur in charge and labelling kinetics. © 1979.

引用

页码：75 / 84

页数：10

共 10 条

[1] TRANSPLANTABLE MURINE SALIVARY-GLAND CARCINOMA (MYOEPITHELIOMA) .1. BIOLOGIC BEHAVIOR AND ULTRASTRUCTURAL FEATURES [J].

DELANEY, WE .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1977, 58 (01) :61-65

[2] ULTRASTRUCTURE OF MORRIS RENAL TUMORS [J].

HRUBAN, Z ;

MOCHIZUKI, Y ;

MORRIS, HP ;

SLESERS, A .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1973, 50 (06) :1487-1495

[3]

IRWIN D, ANAL BIOCH

[4] CLEAVAGE OF STRUCTURAL PROTEINS DURING ASSEMBLY OF HEAD OF BACTERIOPHAGE-T4 [J].

LAEMMLI, UK .

NATURE, 1970, 227 (5259) :680-+

[5]

LAIRD AK, 1969, NATL CANCER I MONOGR, P15

[6]

MALAMUD D, 1978, CANCER RES, V38, P2945

[7]

OTANI TT, 1971, JNCI-J NATL CANCER I, V47, P1247

[8] ISOELECTRIC FOCUSING IN POLYACRYLAMIDE GELS [J].

RIGHETTI, P ;

DRYSDALE, JW .

BIOCHIMICA ET BIOPHYSICA ACTA, 1971, 236 (01) :17-&

[9]

Weber K, 1972, Methods Enzymol, V26, P3

[10]

WINTERS WD, 1974, CANCER RES, V34, P3173

← 1 →