ALTERATIONS OF SLEEPING TIME IN THE RAT INDUCED BY DRUGS WHICH MODULATE CENTRAL MONOAMINERGIC SYSTEMS

被引：20

作者：

ANGEL, A

MAJEED, ABA

机构：

[1] Department of Biomedical Science, University Sheffield

来源：

BRITISH JOURNAL OF ANAESTHESIA | 1990年 / 64卷 / 05期

关键词：

Brain: central monoamines; Sleep;

D O I：

10.1093/bja/64.5.594

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Summary: The effects of adrenoceptor agonists and antagonists have been determined on "sleeping time" in the rat-that is, with the animal immobile and adopting a sleeping posture. Alterations in their gross behaviour patterns were assessed also. The specific α2-adrenoceptor agonists (yohimbine, WY 26393, RX 781094 and RS 21361) decreased sleeping time, as did the β-adrenoceptor agonist clenbuterol. The specific α2-adrenoceptor agonist clonidine gave a large increase in sleeping time at doses in excess of 25 ug kg-1. The same effect was seen with the β-antagonist propranolol and the specific B2-antagonist ICI 118551. © 1990 Copyright: 1990 British Journal of Anaesthesia.

引用

页码：594 / 600

页数：7

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