Salmonella infection remains a major public health problem on a worldwide scale. In developing countries, typhoid fever is a significant cause of morbidity and mortality. This review focuses on three major areas of concern: the need for rapid, specific, sensitive, and easy to use immunodiagnostic tests; the production of an effective vaccine suitable for mass immunization programs; and the therapeutic problems created by the emergence of multiresistant Salmonella typhi in South and Southeast Asia. Foodborne nontyphi salmonella infection has remained a significant health hazard in Europe and the United States. The important role of poultry in the epidemiology of these infections continues to receive attention.