DESMETHYLIMIPRAMINE (DMI) COUNTERACTS LEARNED HELPLESSNESS IN RATS

被引：71

作者：

LESHNER, AI ^{[1
]}

REMLER, H ^{[1
]}

BIEGON, A ^{[1
]}

SAMUEL, D ^{[1
]}

机构：

[1] WEIZMANN INST SCI,DEPT ISOTOPE,REHOVOT 76100,ISRAEL

来源：

PSYCHOPHARMACOLOGY | 1979年 / 66卷 / 02期

关键词：

Desmethylimipramine (DMI); Escape conditioning; Learned helplessness; Rats;

D O I：

10.1007/BF00427633

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In a study of the mechanisms controlling the learned helplessness phenomenon, rats were exposed to either inescapable preshocks or control procedures, treated with one of three dosages of desmethylimipramine, and tested for later adaptive responding. This catecholamine modulator attenuated the deficits in escape responding that ordinarily follow prior exposure to inescapable preshocks, and it did so in a dose-dependent fashion. These findings support the position that the learned helplessnes phenomenon is mediated by catecholamine changes. © 1979 Springer-Verlag.

引用

页码：207 / 208

页数：2

共 6 条

[1] EFFECT OF INESCAPABLE SHOCK ON SUBSEQUENT ESCAPE PERFORMANCE - CATECHOLAMINERGIC AND CHOLINERGIC MEDIATION OF RESPONSE INITIATION AND MAINTENANCE [J].