CHRONIC EFFECT OF KCL ON BLACK-WHITE DIFFERENCES IN PLASMA-RENIN ACTIVITY, ALDOSTERONE, AND URINARY ELECTROLYTES

被引:31
作者
LANGFORD, HG [1 ]
CUSHMAN, WC [1 ]
HSU, H [1 ]
机构
[1] UNIV MISSISSIPPI,MED CTR,DEPT MED,JACKSON,MS 39216
关键词
PLASMA RENIN ACTIVITY; POTASSIUM; CHLORIDE; BLACKS; WHITES;
D O I
10.1093/ajh/4.5.399
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
In a 10-week trial of the effect of 80 mEq KCl/day on blood pressure, the following biochemical changes were noted: plasma renin activity (PRA), originally significantly lower in blacks than whites, increased to the same level as whites after K supplementation. A similar trend was noted with aldosterone. KCl increased creatinine excretion in blacks and whites, and lowered Ca excretion in blacks. These results suggest that the low PRA found in blacks is due, at least in part, to low K intake, and not to genetic causes.
引用
收藏
页码:399 / 403
页数:5
相关论文
共 13 条
[1]  
Langford H.G., Langford F., Tyler M., Dietary profile ofsodium, potassium, and calcium in U.S. blacks, Hypertension inBlacks: Epidemiology, Pathophysiology and Treatment, pp. 49-57, (1985)
[2]  
Prineas R.J., Gillum R., U.S. epidemiology of hypertension in blacks, Hypertension in Blacks: Epidemiology, Pathophysiology and Treatment, pp. 17-36, (1985)
[3]  
Cushman W.C., Langford H.G., Randomized controlled trial of potassium chloride versus placebo inmildly hypertensive blacks and whites (Abst), Circulation, pp. 2-370, (1988)
[4]  
Brunner H.R., Baer L., Sealey J.E., Et al., The influence ofpotassium administration and of potassium deprivationon plasma renin in normal hypertensive subjects, J ClinInvest, 49, 11, pp. 2128-2138, (1970)
[5]  
Smith S.J., Markander N.D., Sagneller G.A., Poston L., Et al., Does potassium lower blood pressure by increasing sodium excretion?, J Hypertens, 2, pp. 27-30, (1983)
[6]  
Julian B.A., Galla J.H., Guthrie G.P., Kotchen T.A., Renin andaldosterone responses to short-term NaCl or NaHC03loading in man, J Lab Clin Med, 100, 2, pp. 261-268, (1982)
[7]  
Davis J.O., Urquhart J., Higgins J.T., Et al., The effect ofalterations of plasma sodium and potassium concentration on aldosterone secretion, J Clin Invest, 42, pp. 597-609, (1963)
[8]  
Langford H.G., Can the black/white differences in bloodpressure and hypertensive mortality in the U.S. be explained by differences in potassium intake?, Potassium in Cardiovascular and Renal Medicine, (1986)
[9]  
Krishna G., Miller E., Kapoor S., Increased blood pressureduring potassium depletion in normotensive men, NEngl J Med, 320, pp. 1177-1182, (1989)
[10]  
Rudman D., Millikan W.J., Richardson R.J., Et al., Elementalbalances during intravenous hyperalimentation of underweight adult subjects, J Clin Invest, 55, pp. 94-104, (1975)