MUSCARINIC RECEPTORS MEDIATE THE RELEASE OF ARACHIDONIC-ACID FROM SPINAL-CORD AND HIPPOCAMPAL-NEURONS IN PRIMARY CULTURE

被引：29

作者：

KANTERMAN, RY

MA, AL

BRILEY, EM

AXELROD, J

FELDER, CC

机构：

[1] NIMH,CELL BIOL LAB,BLDG 36,ROOM 3A-15,BETHESDA,MD 20892

[2] NIH,HOWARD HUGHES MED INST,RES SCHOLARS PROGRAM,BETHESDA,MD 20892

来源：

NEUROSCIENCE LETTERS | 1990年 / 118卷 / 02期

关键词：

Eicosanoid; Inositol phosphate; Phorbol ester; Phospholipase A[!sub]2[!/sub; Phospholipase C; Pirenzepine;

D O I：

10.1016/0304-3940(90)90635-M

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Muscarinic receptors are involved in CNS neurotransmission and have been shown to transduce their message by modulating cAMP, calcium, inositol phosphates, and more recently, by liberating arachidonic acid via phospholipase A1. We have previously shown that the α1-adrenergic and 5-HT2 serotonergic neurotransmitter receptors cause the release of arachidonic acid from spinal cord and hippocampal neurons, respectively, in primary culture. In this study, we demonstrated a muscarinic receptor-mediated release of arachidonic acid in these two neural segments which occurred independent of phosphatidylinositol-specific phospholipase C. This release of arachidonic acid was neuronal (not glial) in origin and exhibited M1 muscarinic receptor pharmacology. © 1990.

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页码：235 / 237

页数：3

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