LOW PREVALENCE OF PRECORE MUTATIONS IN HEPATITIS-B VIRUS-DNA IN FULMINANT-HEPATITIS TYPE-B IN FRANCE

被引：52

作者：

FERAY, C

GIGOU, M

SAMUEL, D

BERNUAU, J

BISMUTH, H

BRECHOT, C

机构：

[1] INST PASTEUR,F-75724 PARIS 15,FRANCE

[2] HOP BEAUJON,UNITE HEPATOL,CLICHY,FRANCE

[3] CHU NECKER,INSERM,U370,PARIS,FRANCE

[4] HOP LAENNEC,UNITE HEPATOL,PARIS,FRANCE

来源：

JOURNAL OF HEPATOLOGY | 1993年 / 18卷 / 01期

关键词：

POLYMERASE CHAIN REACTION; DIRECT SEQUENCING;

D O I：

10.1016/S0168-8278(05)80019-4

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The presence of mutants of the precore region of the hepatitis B virus genome was investigated in French patients with fulminant hepatitis. Only one of the 10 subjects had a detectable mutation by direct sequencing. On the other hand, 2/10 and 3/10 had evidence of coinfection by hepatitis D virus and hepatitis C virus. These results indicate that the precore stop mutation at codon 28 is not a general condition in fulminant hepatitis B and might reflect epidemiological factors.

引用

页码：119 / 122

页数：4

共 14 条

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