COMPARISON OF TOPICAL CIPROFLOXACIN TO CONVENTIONAL ANTIBIOTIC-THERAPY IN THE TREATMENT OF ULCERATIVE KERATITIS

被引:67
作者
PARKS, DJ [1 ]
ABRAMS, DA [1 ]
SARFARAZI, FA [1 ]
KATZ, HR [1 ]
机构
[1] SINAI HOSP,KRIEGER EYE INST,2411 W BELVEDERE AVE,BALTIMORE,MD 21215
关键词
D O I
10.1016/S0002-9394(14)74449-6
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
We evaluated the efficacy of ciprofloxacin (3 mg/ml) as the sole topical antibiotic used to treat infectious keratitis in 14 patients. We compared the ciprofloxacin-treated group to a retrospective control group of 30 consecutive culture-positive patients treated with conventional therapy in which cefazolin (50 mg/ml) and fortified gentamicin sulfate (9.1 mg/ml) solutions were used. We found no remarkable difference between the control group and the ciprofloxacin-treated group regarding patient age, risk factors, need for hospitalization, and virulence of organism isolated. The average time to healing in culture-positive ciprofloxacin-treated patients was 34 +/- 33 days vs 45 +/- 71 days in the control group and this difference was not statistically significant. The duration of antibiotic therapy in the culture-positive ciprofloxacin-treated group was 27 +/- 15 days vs 33 +/- 50 days in the control group. Four of the 30 control patients required modification of their antibiotic regimen, whereas no ciprofloxacin-treated patient required a change. Ciprofloxacin appears to be an effective single agent in the treatment of ulcerative keratitis.
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收藏
页码:471 / 477
页数:7
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