INFRARED ATTENUATED TOTAL REFLECTANCE (ATR) METHOD FOR OBSERVING WATER-MEDIATED SURFACE PHASE REVERSION OF METHYLPREDNISOLONE 2 TO 1 DURING DISSOLUTION

被引：15

作者：

HIGUCHI, WI

HAMLIN, WE

MEHTA, SC

机构：

[1] College of Pharmacy, University of Michigan, Ann Arbor, Michigan

[2] The Pharmacy Research Unit, The Upjohn Company, Kalamazoo, Michigan

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 09期

关键词：

Attenuated total reflectance spectrophotometry–polymorph identity; Methylprednisolone Polymorph II–surface reversion; Polymorph I; Polymorphic reversion–methylprednisolone in water; Solubility–methylprednisolone polymorphs;

D O I：

10.1002/jps.2600580926

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The IR attenuated total reflectance spectrophotometric technique has been employed to demonstrate the surface reversion of methylprednisolone Polymorph II to Polymorph I in the presence of water. The process occurs rapidly enough (minutes) to account for the slower than expected dissolution rates of nondisintegrating pellets of Form II in water. The unusual effects of agitation upon the dissolution rate of Form II pellets are also thus explained. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1145 / &

共 7 条

[1]

BERNARDO PD, 1966, THESIS U MICHIGAN

[2]

BERNARDO PD, TO BE PUBLISHED

[3] LOS OF SENSITIVITY IN DISTINGUISHING REAL DIFFERENCES IN DISSOLUTION RATES DUE TO INCREASING INTENSITY OF AGITATION [J].