BENEFICIAL ACTIONS OF PROSTACYCLIN IN TRAUMATIC SHOCK

被引：42

作者：

LEFER, AM

SOLLOTT, SL

GALVIN, MJ

机构：

[1] Department of Physiology Jefferson Medical College, Thomas Jefferson University Philadelphia

来源：

PROSTAGLANDINS | 1979年 / 17卷 / 05期

关键词：

D O I：

10.1016/S0090-6980(79)80048-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Prostacyclin (PGI2) infused at a rate of 350 ng/kg/min significantly increased survival time in rats subjected to Noble-Collip drum trauma from 2.7±0.3 to 4.6±0.2 h (p<0.01) compared with traumatized rats given only the vehicle (Tris buffer). Moreover, PGI2 treated rats exhibited significantly lower circulating cathepsin D and myocardial depressant factor (MDF) activities, indicative of lower lysosomal disruption and lower toxic factor formation. PGI2 induced vasodilation in rats as well as these other protective effects. © 1979.

引用

页码：761 / 767

页数：7

共 22 条

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