THE USE OF MONOCLONAL-ANTIBODIES IN DIAGNOSTIC-TESTS FOR BECKER AND DUCHENNE MUSCULAR-DYSTROPHY

被引：8

作者：

GOLD, R ^{[1
]}

KRESS, W ^{[1
]}

REICHMANN, H ^{[1
]}

MULLER, CR ^{[1
]}

机构：

[1] UNIV WURZBURG,BIOZENTRUM,INST HUMANGENET,W-8700 WURZBURG,GERMANY

来源：

JOURNAL OF NEUROLOGY | 1993年 / 240卷 / 01期

关键词：

DYSTROPHIN; BECKER MUSCULAR DYSTROPHY; DIAGNOSIS; MONOCLONAL ANTIBODIES;

D O I：

10.1007/BF00838441

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Monoclonal antibodies recognizing different epitopes of dystrophin have now been widely applied in diagnostic tests for Duchenne and Becker muscular dystrophy (BMD). The preservation of the C-terminus in BMD patients necessitates the routine use of one antibody raised against this region. Additional antibodies against deletion-prone regions of dystrophin further increase the diagnostic power of the tests. We describe two cases which illustrate that the combined use of different antibodies is necessary to avoid misdiagnoses of BMD at the protein level.

引用

页码：21 / 24

页数：4

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