EFFECT OF BERENIL ON POLYAMINE METABOLISM IN PRIMARY CULTURED RAT HEPATOCYTES

被引：5

作者：

COLOMBATTO, S

GRILLO, MA

机构：

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY | 1993年 / 25卷 / 06期

关键词：

D O I：

10.1016/0020-711X(93)90241-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. Putrescine and spermidine content increased in hepatocytes during culture. In the presence of 10 muM Berenil, putrescine content was further increased, while the increase of spermidine was prevented. 2. Ornithine decarboxylase activity was markedly reduced, and to a lesser extent also S-adenosylmethionine decarboxylase activity. 3. Berenil appears to promote an increase in the transformation of spermidine into putrescine, and to inhibit the polyamine efflux.

引用

收藏

页码：865 / 868

页数：4

相关论文

共 17 条

[1] 5'-([(Z)-4-AMINO-2-BUTENYL]METHYLAMINO)-5'-DEOXY-ADENOSINE - A POTENT ENZYME-ACTIVATED IRREVERSIBLE INHIBITOR OF S-ADENOSYL-L-METHIONINE DECARBOXYLASE FROM ESCHERICHIA-COLI [J].

CASARA, P ;

MARCHAL, P ;

WAGNER, J ;

DANZIN, C .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (25) :9111-9113

[2] POLYAMINES IN RAT HEPATOCYTE CULTURES [J].

COLOMBATTO, S ;

GRILLO, MA .

BIOLOGICAL CHEMISTRY HOPPE-SEYLER, 1991, 372 (07) :489-493

[3] TRANSPORT AND METABOLISM OF POLYAMINES IN HUMAN-LYMPHOCYTES [J].

COLOMBATTO, S ;

FASULO, L ;

FULGOSI, B ;

GRILLO, MA .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY, 1990, 22 (05) :489-492

[4]

JANNE J, 1971, J BIOL CHEM, V246, P1725

[5] IRREVERSIBLE INHIBITION OF PUTRESCINE-STIMULATED S-ADENOSYL-L-METHIONINE DECARBOXYLASE BY BERENIL AND PENTAMIDINE [J].

KARVONEN, E ;

KAUPPINEN, L ;

PARTANEN, T ;

POSO, H .

BIOCHEMICAL JOURNAL, 1985, 231 (01) :165-169

[6] INHIBITION OF ENZYMES OF POLYAMINE BACK-CONVERSION BY PENTAMIDINE AND BERENIL [J].

LIBBY, PR ;

PORTER, CW .

BIOCHEMICAL PHARMACOLOGY, 1992, 44 (04) :830-832

[7]

LOWRY OH, 1951, J BIOL CHEM, V193, P265

[8] RECENT ADVANCES IN THE BIOCHEMISTRY OF POLYAMINES IN EUKARYOTES [J].

PEGG, AE .

BIOCHEMICAL JOURNAL, 1986, 234 (02) :249-262

[9] INDUCTION OF SPERMIDINE SPERMINE N-1-ACETYLTRANSFERASE BY METHYLGLYOXAL BIS(GUANYLHYDRAZONE) [J].

PEGG, AE ;

ERWIN, BG ;

PERSSON, L .

BIOCHIMICA ET BIOPHYSICA ACTA, 1985, 842 (2-3) :111-118

[10]

PEGG AE, 1987, INHIBITION POLYAMINE, P33