BIOSYNTHESIS OF VITAMIN-B(12) - STRUCTURE OF PRECORRIN-3B, THE TRIMETHYLATED SUBSTRATE OF THE ENZYME CATALYZING RING CONTRACTION

被引：34

作者：

DEBUSSCHE, L ^{[1
]}

THIBAUT, D ^{[1
]}

DANZER, M ^{[1
]}

DEBU, F ^{[1
]}

FRECHET, D ^{[1
]}

HERMAN, F ^{[1
]}

BLANCHE, F ^{[1
]}

VUILHORGNE, M ^{[1
]}

机构：

[1] RHONE POULENC RORER SA,CTR RECH VITRY ALFORTVILLE,DEPT ANAL,13 QUAI JULES GUESDE,BP-14,F-94403 VITRY,FRANCE

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1993年 / 13期

关键词：

D O I：

10.1039/c39930001100

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

FAB-MS, FTIR spectroscopy, C-13 labelling and NMR experiments establish the structure of precorrin-3B, a further trimethylated intermediate along the vitamin B12 pathway, thus demonstrating that precorrin-3B is synthesised from precorrin-3 (called precorrin-3A from now) by a complex oxidative reaction involving C-20 hydroxylation and gamma-lactone formation from ring-A acetate to C-1, catalysed by the CobG protein in Pseudomonas denitrificans.

引用

页码：1100 / 1103

页数：4

共 19 条

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