SINGLET OXYGEN INDUCES COLLAGENASE EXPRESSION IN HUMAN SKIN FIBROBLASTS

被引：106

作者：

SCHARFFETTERKOCHANEK, K

WLASCHEK, M

BRIVIBA, K

SIES, H

机构：

[1] HEINRICH HEINE UNIV DUSSELDORF,INST PHYSIOL CHEM 1,POSTFACH 101007,D-40001 DUSSELDORF,GERMANY

[2] HEINRICH HEINE UNIV DUSSELDORF,HAUTKLIN,DUSSELDORF,GERMANY

来源：

FEBS LETTERS | 1993年 / 331卷 / 03期

关键词：

SINGLET OXYGEN; COLLAGENASE MESSENGER RNA; TIMP MESSENGER RNA; CONNECTIVE TISSUE;

D O I：

10.1016/0014-5793(93)80357-Z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Singlet oxygen generated in a dark reaction by thermodissociation of an endoperoxide (NDPO2) elicits an increase in mRNA of interstitial collagenase (MMP-1) in cultured human fibroblasts. The effect is enhanced in deuterium oxide-based medium and is abolished in the presence of non-toxic doses of sodium azide. In contrast, the mRNA level of the tissue inhibitor of metalloproteinases (TIMP-1) remains unaltered under these experimental conditions. These observations support the suggestion that an unbalanced synthesis of collagenase and TIMP reported to occur following UV-A irradiation or during inflammatory conditions may be mediated by singlet oxygen.

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页码：304 / 306

页数：3

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