OBSTETRICAL AND GYNECOLOGICAL COMPLICATIONS IN FRAGILE-X CARRIERS - A MULTICENTER STUDY

被引：151

作者：

SCHWARTZ, CE

DEAN, J

HOWARDPEEBLES, PN

BUGGE, M

MIKKELSEN, M

TOMMERUP, N

HULL, C

HAGERMAN, R

HOLDEN, JJA

STEVENSON, RE

机构：

[1] GENET & IVF INST,FAIRFAX,VA

[2] VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,RICHMOND,VA 23298

[3] JOHN F KENNEDY INST,DK-2600 GLOSTRUP,DENMARK

[4] CHILDRENS HOSP,DENVER,CO 80218

[5] ONGWANADA RES CTR,KINGSTON,ON,CANADA

来源：

AMERICAN JOURNAL OF MEDICAL GENETICS | 1994年 / 51卷 / 04期

关键词：

IRREGULAR MENSES; FMR1; GENE; OOGONIA; FRAGILE X CARRIERS;

D O I：

10.1002/ajmg.1320510419

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We have conducted a multicenter obstetrical and gynecological survey of women in fragile X families. Included in the study were 131 gene carriers (39 with a full mutation and 92 with a premutation) and 109 noncarriers. Analysis indicated that higher numbers of fragile X gene carriers reported having irregular menses and other gynecological complications. As a group they also experienced cessation of menses prior to age 40 years at a significantly higher rate. The data appear to indicate that the FMR1 gene may play a role in the development and proliferation of oogonia. (C) 1994 Wiley-Liss, Inc.

引用

页码：400 / 402

页数：3

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