GENOTOXICITY OF POLYCHLORINATED-BIPHENYLS (PCBS) - RECOMBINOGENESIS BY BIOTRANSFORMATION PRODUCTS

被引：26

作者：

BUTTERWORTH, FM

PANDEY, P

MCGOWEN, RM

ALISADAT, S

WALIA, S

机构：

[1] Department of Biological Sciences, Oakland University, Rochester

来源：

MUTATION RESEARCH-GENETIC TOXICOLOGY | 1995年 / 342卷 / 1-2期

关键词：

RECOMBINATION; POLYCHLORINATED BIPHENYL; METABOLITE; DROSOPHILA; GENOTOXICITY;

D O I：

10.1016/0165-1218(95)90090-X

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A coplanar polychlorinated biphenyl (PCB) when eaten by test animals increased the rate of recombination in somatic cells, indicating a new mechanism of action for these compounds. Using the eye-mosaic test a high bioactivation strain of Drosophila that consumed 4,4'-dichlorobiphenyl (4,4'-DCB) manifested a genotoxicity rate that was three-fold greater than that in animals fed the solvent-spiked medium. This compound was not genotoxic in a suppressed bioactivation strain indicating that genotoxicity requires bioactivation of the compound. High bioactivation test strains made heterozygous for a paracentric inversion, a chromosomal rearrangement that suppresses homologous recombination, exhibited significantly reduced genotoxicity after treatment.

引用

页码：61 / 69

页数：9

共 48 条

[1] VOLATILIZATION OF POLYCHLORINATED-BIPHENYLS FROM GREEN BAY, LAKE-MICHIGAN [J].