GENOTOXICITY OF POLYCHLORINATED-BIPHENYLS (PCBS) - RECOMBINOGENESIS BY BIOTRANSFORMATION PRODUCTS

被引:26
作者
BUTTERWORTH, FM
PANDEY, P
MCGOWEN, RM
ALISADAT, S
WALIA, S
机构
[1] Department of Biological Sciences, Oakland University, Rochester
来源
MUTATION RESEARCH-GENETIC TOXICOLOGY | 1995年 / 342卷 / 1-2期
关键词
RECOMBINATION; POLYCHLORINATED BIPHENYL; METABOLITE; DROSOPHILA; GENOTOXICITY;
D O I
10.1016/0165-1218(95)90090-X
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
A coplanar polychlorinated biphenyl (PCB) when eaten by test animals increased the rate of recombination in somatic cells, indicating a new mechanism of action for these compounds. Using the eye-mosaic test a high bioactivation strain of Drosophila that consumed 4,4'-dichlorobiphenyl (4,4'-DCB) manifested a genotoxicity rate that was three-fold greater than that in animals fed the solvent-spiked medium. This compound was not genotoxic in a suppressed bioactivation strain indicating that genotoxicity requires bioactivation of the compound. High bioactivation test strains made heterozygous for a paracentric inversion, a chromosomal rearrangement that suppresses homologous recombination, exhibited significantly reduced genotoxicity after treatment.
引用
收藏
页码:61 / 69
页数:9
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