PLASMA AND CEREBROSPINAL-FLUID TRYPTOPHAN IN MULTIPLE-SCLEROSIS AND DEGENERATIVE DISEASES

被引：91

作者：

MONACO, F ^{[1
]}

FUMERO, S ^{[1
]}

MONDINO, A ^{[1
]}

MUTANI, R ^{[1
]}

机构：

[1] RBM INST BIOMED RES,IVREA,ITALY

来源：

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 1979年 / 42卷 / 07期

关键词：

D O I：

10.1136/jnnp.42.7.640

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Tryptophan and competing neutral amino acid levels were found to be diminished in the plasma of patients with multiple sclerosis and degenerative diseases, the greatest decrease being of tryptophan. Cerebrospinal fluid tryptophan was decreased in multiple sclerosis and motor neurone disease, while leucine and valine were increased. These changes might lead to decreased synthesis of brain serotonin and brain proteins. The ratio between neutral amino acids and tryptophan might be used as an ancillary test in the screening of degenerative diseases.

引用

页码：640 / 641

页数：2

共 9 条

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